Archive for the ‘Vitamin D’ Category

Vitamin D: Don’t Overdo a Good Thing

Thursday, September 24th, 2015

Came across a sensible article on vitamin D supplementation today. Thanks, Jeff!

Vitamin D: Don’t Overdo a Good Thing by Tod Cooperman, M.D.

Excerpt:

“It seems that initial reports led some experts to ignore the recommendation of the National Academies’ Institute of Medicine, which says that only people with vitamin D levels under 20 ng/mL are deficient. Instead, these experts argued that people need to maintain levels which are at least 50 percent higher–30 ng/mL….Further feeding this frenzy have been clinical laboratories — which profit from more vitamin D tests. When you get a vitamin D test back, the “normal” range shown next to your result often extends up to 100 ng/mL (which is actually far beyond the normal range), leading people with levels in the 20s, for example, to believe they needed more vitamin D.”

Vitamin D3 Performs Slightly Better Than D2 in Clinical Trial

Tuesday, June 23rd, 2015

I have updated the VeganHealth.org article, Calcium and Vitamin D, with a synopsis of the following clinical trial:

“A 2013 study from Germany found that with supplementing daily for 8 weeks at about 2,000 IU, D3 was more effective at raising vitamin D levels (1). The average 25(OH)D levels increased 46 nmol/l in the D3 group (for an average of 89 nmol/l) but only 30 nmol/l in the D2 group (for an average of 68 nmol/l). Vitamin D2 supplementation appeared to decrease the amount of circulating vitamin D3. PTH levels were not different between groups. Because D2 raised levels into the recommended range (50 – 125 nmol/l), it seems preliminary to assume that D3 is more healthy based on these results, though evidence is mounting that D3, even at smaller doses, can raise vitamin D levels higher or more quickly than D2.”

I don’t think this has any health implications for most vegans. If you have experienced a stubborn vitamin D deficiency, it adds some credence to the idea that you should try vitamin D3. Vegan vitamin D3 is available.

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References

1. Lehmann U, Hirche F, Stangl GI, Hinz K, Westphal S, Dierkes J. Bioavailability of vitamin D(2) and D(3) in healthy volunteers, a randomized placebo-controlled trial. J Clin Endocrinol Metab. 2013 Nov;98(11):4339-45. doi: 10.1210/jc.2012-4287. Epub 2013 Sep 3. | link

Vitamin D is Absorbed Better with Fat

Sunday, May 24th, 2015

I have updated the article, Calcium and Vitamin D, to reflect recent research showing that vitamin D supplements are better absorbed when taken with meals that contain fat.

The study was a randomized controlled trial conducted at Tufts University (1). It compared taking a 50,000 IU dose of vitamin D3 with three different meals: 1) a fat-free meal, 2) a 30% fat meal with high polyunsaturated fats, 3) a 30% fat meal with high monounsaturated fats. To make a short story even shorter, the meals with fat increased vitamin D absorption 32% over the meals without. There was no difference between meals high in polyunsaturated and monounsaturated fats.

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Registered Dietitians and Medical Doctors can earn continuing education credits at the upcoming Plant-based Prevention of Disease Conference.

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References

1. Dawson-Hughes B, Harris SS, Lichtenstein AH, Dolnikowski G, Palermo NJ, Rasmussen H. Dietary fat increases vitamin D-3 absorption. J Acad Nutr Diet. 2015 Feb;115(2):225-30. | link

Medscape Report: Calcium & Vitamin D Decreases Fractures & Cancer

Monday, April 28th, 2014

On April 2, 2014, Medscape sent out a Special Report that included a link to a video and article, Calcium + Vitamin D: Surprises From Long-term Follow-up. You probably need to sign up for a free account to view the article.

Here are some excerpts from the article which was about the Women’s Health Initiative study:

“In this large trial, more than 36,000 postmenopausal women aged 50-79 years were randomly assigned to treatment with a combination of calcium carbonate at a dose of 1000 mg elemental calcium plus vitamin D3 400 IU daily, or placebo.

“We now have 3 lines of evidence of benefit for calcium plus vitamin D supplementation: the reduction in hip fracture seen among adherent women, the reduction in vertebral fracture in the intention-to-treat analyses, and the improvement or better results for bone mineral density…

“In terms of all cancers, among the women who had low baseline intake of vitamin D, there was a statistically significant 9% reduction in total cancer with supplementation, and also a marginally significant 9% reduction in all-cause mortality.”

The report also said that there was no increase in cardiovascular disease for women taking supplements.

Amy’s Gluten-Free Vegan Burritos and other Odds and Ends

Tuesday, January 7th, 2014

Gluten-Free Vegan Burrito

Amy’s has a gluten-free, vegan burrito. More info.

Vitamin D & Bone Pain: A Study of One

I received a nice note from a reader:

“You may want to know that after reading your book and watching your presentation at the Vegetarian Society of Hawaii, I started taking Vitamin D in winter and autumn, which “cured” my muscular pain. Also, your recommendations helped my mother fix her high homocysteine level. Since she is vegetarian and not vegan, I thought she needed just a little B12 (wrong!).”

Food for Thought: Adopting an animal-friendly menu policy

If you are involved with an animal shelter that doesn’t serve vegan food at their functions, check out Animal Place’s Food for Thought campaign which strives to make shelter events friendly to all animals. More info.

Eyes

Dr. Greger just finished releasing a 4-part video series on nutrition and eyesight that I found very informative. Link.

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Do Calcium and Vitamin D Need to be Taken Together?

Friday, June 14th, 2013

I’ve received this question twice in the past week, so thought I’d turn it into a post in case other people are wondering the same thing:

“Do you have any view on whether calcium and Vitamin D supplements should be taken at the same time to ensure they are absorbed properly? This seems to be the reason that calcium and Vitamin D are often sold in the same pill. Alternatively, if you aim to get Vitamin D from sunshine, should you wait to take the calcium supplement at that point of the day?”

There is no need to take vitamin D (or get sun) at the same time as you eat calcium. The vitamin D that you eat needs to be absorbed into your blood and then taken to the liver to be modified into a circulating, storage form of vitamin D known as 25(OH)D. Then, when your body senses that you need to absorb more calcium, the kidney further modifies the 25(OH)D into the hormone calcitriol. Calcitriol then increases calcium absorption. Vitamin D ingestion at a single meal will not have an effect on calcium absorption at that meal.

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I haven’t checked out any new music lately, so I’m going to highlight some of my favorite music to work to:

Juana Molina: Vive Solo

Marco Beltrami & Buck Sanders: I Wanna Hold Your Hand

Philip Glass: Wichita Sutra Vortex

Philip Glass: Facades

Philip Glass: Metamorphosis: Metamorphosis Four

Philip Glass: Opening

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Errata: Recommended D Levels & Mustard Green Ca Content

Tuesday, April 2nd, 2013

Two errata:

1. On p. 8 of the Executive Summary for their 2010 Dietary Reference Intakes for Calcium and Vitamin D, the Institute of Medicine says that they are basing their recommendations on a vitamin D level of 16 to 20 ng/ml of 25(OH)D. I have been using that as the level to indicate adequate vitamin D. But later in the document (p. 14), they talk about ideal levels some more and conclude that less than 20 ng/dl might be potentially too low for some people and therefore they recommend at least 20 ng/ml.

I have changed the levels in my calcium and vitamin D articles to reflect this. (Thanks, Brandon!)

2. In the table of calcium in plant foods, I had listed the wrong amount of calcium in a 1/2 cup serving of “Mustard greens ā€“ frozen, cooked, boiled, drained, chopped” as 107 mg. It is actually 76 mg.

Calcium and Vitamin D for Vegans: Summarized!

Wednesday, March 20th, 2013

This is an abridged version of Calcium and Vitamin D, which includes references and more details on just about every paragraph below.

Calcium

Americans are regularly being urged to consume more calcium in order to prevent osteoporosis. It is practically impossible to meet the recommendations without large amounts of cows’ milk, calcium-fortified foods, or supplements.

Because vegans do not eat dairy products, without fortified foods or supplements their calcium intakes tend to be low (about 400-600 mg per day compared to the U.S. recommended intake of 1,000 mg per day).

Traditionally, the vegan community has responded to this by saying osteoporosis is a disease of calcium loss from the bones, not a lack of calcium in the diet. This was based on two ideas.

The first idea is that ecological studies have shown that the countries with the highest intake of dairy products (northern Europe and the USA) have higher rates of hip fractures than do Asian and African countries where much less milk is consumed. This in turn, can be explained by the second idea, which is that studies show that after ingesting animal protein, people urinate large amounts of calcium.

Therefore, the thinking goes, calcium intake isn’t important for preventing osteoporosis and vegans are protected due to the lack of animal protein in their diets.

Unfortunately, there is a lot of evidence to suggest that this is not correct. It turns out that hip fractures are more indicative of the risk of falling than of osteoporosis in some countries, with a recent study from Hong Kong showing that while men and women in Hong Kong had lower rates of hip fractures, they had higher rates of vertebral factures, and the women had higher rates of osteoporosis than Caucasian women.

As for protein leaching calcium from bones into the urine – it’s a lot more complicated than that. The studies that showed calcium to be urinated out were done using protein isolates whereas eating protein from whole foods does not result in a calcium imbalance. Population studies and clinical trials show that protein, including animal protein, does not have a negative effect on bones (more details here).

So where does that leave vegans?

Vegans’ bone mineral density, a measure of osteoporosis, has been shown in many studies to be slightly lower than non-vegans. More importantly, the one study on Western vegans measuring fracture rates over time found that vegans in the group who got less than 525 mg of calcium per day had a higher fracture rate than vegans in the group getting more than 525 mg. The vegans in the lower calcium group also had higher fracture rates than the meat-eaters and lacto-ovo vegetarians.

Although it is possible to meet the calcium recommendations by eating greens alone, the average vegan probably will not meet recommendations without drinking a glass of fortified drink each day, eating calcium-set tofu, or taking a 250 – 300 mg supplement (in addition to eating an otherwise balanced diet).

The greens highest in absorbable calcium are kale, mustard greens, bok choy, turnip greens, collards, and watercress (more info). In addition to calcium, greens also contain vitamin K, potassium, and magnesium, which also contribute to better bone health.

While spinach, Swiss chard, and beet greens are high in calcium, it is not well absorbed due to their also high content of oxalates, which bind calcium and prevent absorption from the digestive tract.

Research is mixed about whether calcium intakes above 1,400 mg per day can put people at risk for chronic disease. If you take a calcium supplement, it’s best not to go overboard. Most vegans taking 250-300 mg per day would not come close to 1,400 mg.

Vitamin D

Vitamin D is also important for bones, as it can increase calcium absorption when the body signals that it needs calcium. Research has shown that in populations with calcium intakes similar to omnivores in the United States, vitamin D is more important than calcium for preventing osteoporosis.

In recent years, vitamin D has also been linked to many other diseases and some researchers have suggested that the recommended vitamin D levels are too low. However, the Institute of Medicine has reviewed the research and concluded that is not the case. The controversy has resulted in many people thinking they are deficient in vitamin D when they are not.

The only significant, natural, dietary sources of vitamin D are fatty fish, eggs (if chickens have been fed vitamin D), and mushrooms (if treated with UV rays). Most Americans get their dietary vitamin D through fortified milk and fortified margarine. The vegan diet contains little, if any, vitamin D without fortified foods or supplements. On average, vegans’ vitamin D levels are adequate, but somewhat lower than non-vegans.

Most people get a significant amount of their vitamin D from the action of UV rays on their skin. While the body can store vitamin D made in the sunnier months for use during less sunny times, this does not work for everyone. In fact, some people, even those living in sunny climates, develop extremely low levels of vitamin D. This can manifest itself through fatigue and bone pain.

If your arms and face (or the equivalent amount of skin or more) is exposed to the following amounts of midday sun (10 am to 2 pm), without sunscreen, on a day when sunburn is possible (i.e., not winter or cloudy), then you should not need any dietary vitamin D that day:

• Light-skinned: 10 to 15 minutes
• Dark-skinned: 20 minutes
• Elderly: 30 minutes

On all other days, people older than one year should get 600 to 1,000 IU of vitamin D.

Due to skin cancer concerns, some dermatologists recommend getting all your vitamin D from supplements rather than the sun. The amounts of sun above for light and dark-skinned people should be safe, but I have not seen research on how much sun is safe for elderly people and recommend talking to your doctor about how to get vitamin D if you believe you are at risk for skin cancer.

600 to 1,000 IU of vitamin D is only available in supplemental form or specially treated mushrooms.

There are two forms of supplemental vitamin D: D2 and D3. Vitamin D2 is always vegan, made from exposing fungi to UV rays. Vitamin D3 normally comes from fish oil or sheep’s wool, but there is a vegan version made by Vitashine.

A great deal of research has been conducted on vitamin D2 and D3. Vitamin D2 is effective at increasing bone mineral density (when given to people who are deficient). Vitamin D2 can also increase vitamin D levels temporarily, but is not as effective as vitamin D3 at keeping vitamin D levels raised when taken only weekly. If you take vitamin D on a regular basis, D2 should be fine, whereas if you are only going to take it sporadically, without getting sun in the interim, or find that your vitamin D levels will not increase on D2, then you should opt for D3.

If you are trying to raise your vitamin D levels with D2, make sure the laboratory can detect vitamin D2, and not just vitamin D3. Also make sure that you are not trying to raise your levels beyond what the Institute of Medicine says is adequate (50 nmol/l or 20 ng/ml) as there’s no sense in worrying if you cannot seem to get your vitamin D levels twice as high as necessary!

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VeganHealth.org: Vitamin D2 in Mushrooms

Monday, March 11th, 2013

I added some research on vitamin D2 in mushrooms to the Bones, Vitamin D, and Calcium page at VeganHealth.org:

Vitamin D2 in UV Treated Mushrooms

Food manufacturers are now creating large amounts of vitamin D2 in mushrooms by exposing them to commercial ultraviolet light or direct sunlight (55, 56). The vitamin D is well-retained in the mushrooms over the course of the typical storage life of fresh mushrooms, up to two weeks (55, 57). This vitamin D is effective in improving vitamin D status and no different from a vitamin D2 supplement (2).

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References

2. Urbain P, Singler F, Ihorst G, Biesalski HK, Bertz H. Bioavailability of
vitamin Dā‚‚ from UV-B-irradiated button mushrooms in healthy adults deficient in
serum 25-hydroxyvitamin D: a randomized controlled trial. Eur J Clin Nutr. 2011
Aug;65(8):965-71. doi: 10.1038/ejcn.2011.53. Epub 2011 May 4. | link

55. Kalaras MD, Beelman RB, Elias RJ. Effects of postharvest pulsed UV light treatment of white button mushrooms (Agaricus bisporus) on vitamin D2 content and quality attributes. J Agric Food Chem. 2012 Jan 11;60(1):220-5. | link

56. Simon RR, Phillips KM, Horst RL, Munro IC. Vitamin D mushrooms: comparison of the composition of button mushrooms (Agaricus bisporus) treated postharvest with UVB light or sunlight. J Agric Food Chem. 2011 Aug 24;59(16):8724-32. | link

57. Roberts JS, Teichert A, McHugh TH. Vitamin D2 formation from post-harvest UV-B treatment of mushrooms (Agaricus bisporus) and retention during storage. J Agric Food Chem. 2008 Jun 25;56(12):4541-4. | link

VeganHealth.org Update: Vitamin D2 vs. D3

Sunday, March 10th, 2013

In continuing to bone up on the bones research, I have summarized some recent findings on vitamin D2 vs. D3 and updated the Bones, Vitamin D, and Calcium page at VeganHealth.org.

So that I do not have to continue updating this page to reflect the VeganHealth.org page, I have cut the article from this post and readers should just refer to the link above. Thank you.

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